Knuckling after Bedinvetmab (Librela) in dogs

469 reports to the FDA describe knuckling in dogs given Bedinvetmab. That is 2.4% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

469Reports

76%Marked serious

7.2%Recovered

33%Died or euthanised

10 daysTypical onset

How soon it started

Same day

83 21%

1–2 days

64 16%

3–7 days

43 11%

1–4 weeks

88 22%

Over a month

120 30%

How the animals did

Recovered

34 7.2%

Still unwell when reported

235 50%

Died

33 7.0%

Euthanised

124 26%

Not known

43 9.2%

Problems reported at the same time

Weakness

163 35%

Death

159 34%

Wobbliness (ataxia)

138 29%

Proprioception deficit

89 19%

Breathing problems

78 17%

Unable to walk

75 16%

Loss of appetite

63 13%

Musculoskeletal disorder

61 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

165

12+ years

261

About this medicine

Bedinvetmab reduces osteoarthritis pain in dogs (monthly injection).

Products with this ingredient include Librela. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Bedinvetmab cause knuckling in dogs?: 469 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 10 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Bedinvetmab in dogs · Medicines most reported with knuckling