Cardiac enlargement after Bedinvetmab (Librela) in dogs

The FDA has received 81 reports of cardiac enlargement in dogs after Bedinvetmab. That is 0.4% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

81Reports

94%Marked serious

1.2%Recovered

48%Died or euthanised

14 daysTypical onset

How soon it started

Same day

8 11%

1–2 days

9 13%

3–7 days

8 11%

1–4 weeks

25 35%

Over a month

21 30%

How the animals did

Recovered

1 1.2%

Still unwell when reported

40 49%

Died

11 14%

Euthanised

28 35%

Not known

1 1.2%

Problems reported at the same time

Death

39 48%

Breathing problems

31 38%

Abnormal radiograph finding

29 36%

28 35%

23 28%

22 27%

20 25%

18 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Bedinvetmab reduces osteoarthritis pain in dogs (monthly injection).

Products with this ingredient include Librela. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Bedinvetmab cause cardiac enlargement in dogs?: 81 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Cardiac enlargement with similar medicines

Cardiac enlargement after Lokivetmab (Cytopoint) 20 reports · 0.3% of its reports

All reported side effects of Bedinvetmab in dogs · Medicines most reported with cardiac enlargement