Didn't work as expected after Alprazolam in dogs

The FDA has received 68 reports of didn't work as expected in dogs after Alprazolam. That is 17% of all reports for this medicine, compared with 13% across reports for all dog medicines.

68Reports

25%Marked serious

13%Recovered

2.9%Died or euthanised

39 daysTypical onset

How soon it started

Same day

3 7.5%

1–2 days

4 10%

3–7 days

6 15%

1–4 weeks

6 15%

Over a month

21 53%

How the animals did

Recovered

8 12%

Recovered with lasting effects

1 1.5%

Still unwell when reported

13 19%

Euthanised

2 2.9%

Not known

44 65%

Problems reported at the same time

Vomiting

7 10%

Loss of appetite

6 8.8%

Anxiety

5 7.4%

Didn't stop worms

5 7.4%

Lethargy

5 7.4%

Pacing

4 5.9%

Itching

4 5.9%

Behaviour change

3 4.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Alprazolam cause didn't work as expected in dogs?: 68 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 39 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Melarsomine (Immiticide) 646 reports · 2.8% of its reports
Didn't work as expected after Polysulfated Glycosaminoglycan 698 reports · 13% of its reports
Didn't work as expected after Diphenhydramine 585 reports · 12% of its reports
Didn't work as expected after Butorphanol 1,022 reports · 23% of its reports
Didn't work as expected after Cefpodoxime 671 reports · 17% of its reports
Didn't work as expected after Tramadol 475 reports · 13% of its reports
Didn't work as expected after Florfenicol + Mometasone + Terbinafine 969 reports · 27% of its reports
Didn't work as expected after Desoxycorticosterone Pivalate 355 reports · 11% of its reports
Didn't work as expected after Propofol 600 reports · 20% of its reports
Didn't work as expected after Dirlotapide 712 reports · 25% of its reports

All reported side effects of Alprazolam in dogs · Medicines most reported with didn't work as expected