Behaviour change after Alprazolam in dogs

The FDA has received 26 reports of behaviour change in dogs after Alprazolam. That is 6.5% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports
35%Marked serious
23%Recovered
7.7%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
5 23%
1–2 days
5 23%
3–7 days
2 9.1%
1–4 weeks
5 23%
Over a month
5 23%

How the animals did

Recovered
5 19%
Recovered with lasting effects
1 3.8%
Still unwell when reported
10 38%
Died
2 7.7%
Not known
8 31%

Problems reported at the same time

8 31%
4 15%
Restlessness or agitation
4 15%
Itching
4 15%

Age of the animals

Under 1 year
0
1–3 years
7
4–7 years
8
8–11 years
5
12+ years
5

About this medicine

Type: medicine.

Questions owners ask

Can Alprazolam cause behaviour change in dogs?
26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Alprazolam in dogs · Medicines most reported with behaviour change