Elevated lipase after Velagliflozin (Senvelgo) in cats

The FDA has received 42 reports of elevated lipase in cats after Velagliflozin. That is 0.9% of all reports for this medicine, compared with 0.2% across reports for all cat medicines, so it is reported unusually often with this medicine.

42Reports

62%Marked serious

2.4%Recovered

38%Died or euthanised

11 daysTypical onset

How soon it started

Same day

3 8.6%

1–2 days

5 14%

3–7 days

8 23%

1–4 weeks

8 23%

Over a month

11 31%

How the animals did

Recovered

1 2.4%

Still unwell when reported

7 17%

Died

3 7.1%

Euthanised

13 31%

Not known

18 43%

Problems reported at the same time

26 62%

26 62%

25 60%

21 50%

19 45%

19 45%

17 40%

16 38%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Velagliflozin treats diabetes in cats (oral, an SGLT2 inhibitor).

Products with this ingredient include Senvelgo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Velagliflozin cause elevated lipase in cats?: 42 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 11 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated lipase with similar medicines

Elevated lipase after Bexagliflozin (Bexacat) 41 reports · 1.0% of its reports
Elevated lipase after Insulin 22 reports · 0.6% of its reports

All reported side effects of Velagliflozin in cats · Medicines most reported with elevated lipase