Decreased urine concentration after Velagliflozin (Senvelgo) in cats

The FDA has received 22 reports of decreased urine concentration in cats after Velagliflozin. That is 0.5% of all reports for this medicine, compared with 0.4% across reports for all cat medicines.

22Reports

27%Marked serious

0.0%Recovered

18%Died or euthanised

11 daysTypical onset

How soon it started

Same day

2 9.5%

1–2 days

1 4.8%

3–7 days

6 29%

1–4 weeks

7 33%

Over a month

5 24%

How the animals did

Still unwell when reported

3 14%

Died

1 4.5%

Euthanised

3 14%

Not known

15 68%

Problems reported at the same time

12 55%

11 50%

9 41%

8 36%

Elevated symmetrical dimethylarginine (sdma)

7 32%

Didn't work as expected

6 27%

Hypokalaemia

5 23%

Ketosis

5 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Velagliflozin treats diabetes in cats (oral, an SGLT2 inhibitor).

Products with this ingredient include Senvelgo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Velagliflozin cause decreased urine concentration in cats?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 11 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased urine concentration with similar medicines

Decreased urine concentration after Bexagliflozin (Bexacat) 25 reports · 0.6% of its reports

All reported side effects of Velagliflozin in cats · Medicines most reported with decreased urine concentration