Elevated symmetrical dimethylarginine (sdma) after Velagliflozin (Senvelgo) in cats

The FDA has received 142 reports of elevated symmetrical dimethylarginine (sdma) in cats after Velagliflozin. That is 3.0% of all reports for this medicine, compared with 0.5% across reports for all cat medicines, so it is reported unusually often with this medicine.

142Reports
25%Marked serious
0.7%Recovered
9.2%Died or euthanised
21 daysTypical onset
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How soon it started

Same day
8 6.5%
1–2 days
13 10%
3–7 days
21 17%
1–4 weeks
29 23%
Over a month
53 43%

How the animals did

Recovered
1 0.7%
Still unwell when reported
21 15%
Died
3 2.1%
Euthanised
10 7.0%
Not known
107 75%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
4
8–11 years
23
12+ years
113

About this medicine

Velagliflozin treats diabetes in cats (oral, an SGLT2 inhibitor).

Products with this ingredient include Senvelgo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Velagliflozin cause elevated symmetrical dimethylarginine (sdma) in cats?
142 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 21 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated symmetrical dimethylarginine (sdma) with similar medicines

All reported side effects of Velagliflozin in cats · Medicines most reported with elevated symmetrical dimethylarginine (sdma)