Didn't work as expected after Tiletamine + Zolazepam in cats

The FDA has received 265 reports of didn't work as expected in cats after Tiletamine + Zolazepam. That is 16% of all reports for this medicine, compared with 8.7% across reports for all cat medicines, so it is reported unusually often with this medicine.

265Reports

35%Marked serious

33%Recovered

23%Died or euthanised

Same dayTypical onset

How soon it started

Same day

122 88%

1–2 days

7 5.1%

3–7 days

2 1.4%

1–4 weeks

3 2.2%

Over a month

4 2.9%

How the animals did

Recovered

87 33%

Still unwell when reported

5 1.9%

Died

15 5.7%

Euthanised

47 18%

Not known

111 42%

Problems reported at the same time

26 9.8%

21 7.9%

9 3.4%

6 2.3%

6 2.3%

Restlessness or agitation

6 2.3%

Behaviour change

6 2.3%

Incorrect route of drug administration

5 1.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Tiletamine + Zolazepam cause didn't work as expected in cats?: 265 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Ketamine 586 reports · 18% of its reports
Didn't work as expected after Butorphanol 220 reports · 9.8% of its reports
Didn't work as expected after Isoflurane 144 reports · 7.1% of its reports
Didn't work as expected after Methylprednisolone 227 reports · 14% of its reports
Didn't work as expected after Propofol 81 reports · 6.9% of its reports
Didn't work as expected after Atipamezole 120 reports · 12% of its reports
Didn't work as expected after Midazolam 31 reports · 4.1% of its reports
Didn't work as expected after Florfenicol + Mometasone + Terbinafine 42 reports · 6.1% of its reports
Didn't work as expected after Orbifloxacin 76 reports · 11% of its reports
Didn't work as expected after Molidustat 194 reports · 32% of its reports

All reported side effects of Tiletamine + Zolazepam in cats · Medicines most reported with didn't work as expected