Not drinking after Sarolaner + Selamectin (Revolution Plus) in cats

94 reports to the FDA describe not drinking in cats given Sarolaner + Selamectin. That is 1.1% of all reports for this medicine, compared with 1.1% across reports for all cat medicines.

94Reports
60%Marked serious
17%Recovered
15%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
46 50%
1–2 days
27 29%
3–7 days
15 16%
1–4 weeks
3 3.3%
Over a month
1 1.1%

How the animals did

Recovered
16 17%
Still unwell when reported
40 43%
Died
5 5.3%
Euthanised
9 9.6%
Not known
24 26%

Problems reported at the same time

Age of the animals

Under 1 year
20
1–3 years
20
4–7 years
20
8–11 years
11
12+ years
19

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly. Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this combination include Revolution Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner + Selamectin cause not drinking in cats?
94 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not drinking with similar medicines

All reported side effects of Sarolaner + Selamectin in cats · Medicines most reported with not drinking