Liver problems after Oclacitinib (Apoquel) in cats

71 reports to the FDA describe liver problems in cats given Oclacitinib. That is 15% of all reports for this medicine, compared with 2.8% across reports for all cat medicines, so it is reported unusually often with this medicine.

71Reports

77%Marked serious

9.9%Recovered

31%Died or euthanised

Same dayTypical onset

How soon it started

Same day

37 58%

1–2 days

11 17%

3–7 days

2 3.1%

1–4 weeks

6 9.4%

Over a month

8 13%

How the animals did

Recovered

7 9.9%

Still unwell when reported

39 55%

Died

8 11%

Euthanised

14 20%

Not known

3 4.2%

Problems reported at the same time

46 65%

39 55%

30 42%

28 39%

26 37%

22 31%

20 28%

14 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause liver problems in cats?: 71 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Cyclosporine (Atopica) 145 reports · 4.8% of its reports

All reported side effects of Oclacitinib in cats · Medicines most reported with liver problems