Oclacitinib (Apoquel) side effects in cats

463 reports sent to the FDA between 2014 and 2026 involve Oclacitinib in cats. The most reported problems were accidental exposure, kidney problems, vomiting. 51% were marked serious, and where it was recorded, signs eased after stopping the medicine in 20% of cases.

463Reports
51%Marked serious
60%Only medicine involved
9.1%Recovered
16%Died or euthanised
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About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Most reported side effects

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a cat still getting fleas or heartworm), not about a side effect.

Didn't stop fleas
2 0.4%
Didn't stop mites
1 0.2%
Didn't prevent heartworm
1 0.2%

How soon problems started

Same day
154 41%
1–2 days
51 14%
3–7 days
31 8.3%
1–4 weeks
46 12%
Over a month
91 24%

Time from the first dose to the first sign, where both dates were reported (373 reports).

How the animals did

Recovered
42 9.1%
Still unwell when reported
282 61%
Died
33 7.1%
Euthanised
40 8.6%
Not known
66 14%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other anti-itch medicines for cats