Allergic reaction after Fluralaner + Moxidectin (Bravecto Plus) in cats

22 reports to the FDA describe allergic reaction in cats given Fluralaner + Moxidectin. That is 0.7% of all reports for this medicine, compared with 0.9% across reports for all cat medicines.

22Reports
73%Marked serious
23%Recovered
4.5%Died or euthanised
Same dayTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
15 83%
1–2 days
2 11%
3–7 days
0 0.0%
1–4 weeks
0 0.0%
Over a month
1 5.6%

How the animals did

Recovered
5 23%
Still unwell when reported
13 59%
Died
1 4.5%
Not known
3 14%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
11
4–7 years
6
8–11 years
1
12+ years
1

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Bravecto Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner + Moxidectin cause allergic reaction in cats?
22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Allergic reaction with similar medicines

All reported side effects of Fluralaner + Moxidectin in cats · Medicines most reported with allergic reaction