Febantel + Praziquantel + Pyrantel (Drontal Plus) side effects in cats

70 reports sent to the FDA between 2000 and 2025 involve Febantel + Praziquantel + Pyrantel in cats. The most reported problems were vomiting, loss of appetite, lethargy. 37% were marked serious.

70Reports
37%Marked serious
64%Only medicine involved
33%Recovered
5.7%Died or euthanised
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About this medicine

Febantel treats intestinal worms. Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Drontal Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Most reported side effects

30 43%
Lethargy
18 26%
Wobbliness (ataxia)
17 24%
Drooling
15 21%
Diarrhea
8 11%
Drug administration error
7 10%
Adipsia
5 7.1%
Fever
4 5.7%
Accidental exposure
4 5.7%
Itching
4 5.7%
Behaviour change
4 5.7%
Weight loss
4 5.7%
Nystagmus
4 5.7%
Restlessness or agitation
3 4.3%

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a cat still getting fleas or heartworm), not about a side effect.

Didn't stop worms
1 1.4%
Didn't work as expected
1 1.4%

How soon problems started

Same day
25 56%
1–2 days
11 24%
3–7 days
3 6.7%
1–4 weeks
3 6.7%
Over a month
3 6.7%

Time from the first dose to the first sign, where both dates were reported (45 reports).

How the animals did

Recovered
23 33%
Still unwell when reported
13 19%
Died
4 5.7%
Not known
30 43%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other dewormers for cats