Pyrantel + Sarolaner (Simparica Trio) side effects in cats

50 reports sent to the FDA between 2021 and 2026 involve Pyrantel + Sarolaner in cats. The most reported problems were accidental exposure, tremors, vomiting. 44% were marked serious.

50Reports
44%Marked serious
88%Only medicine involved
10%Recovered
0.0%Died or euthanised
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About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Most reported side effects

Accidental exposure
19 38%
Tremors
12 24%
Vomiting
12 24%
Itching
11 22%
Seizures
10 20%
Lethargy
8 16%
Breathing problems
7 14%
Loss of appetite
6 12%
Behaviour change
5 10%
Drooling
4 8.0%
Wobbliness (ataxia)
3 6.0%
Diarrhea
3 6.0%
Fever
3 6.0%
Tachycardia
2 4.0%
Restlessness or agitation
2 4.0%

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a cat still getting fleas or heartworm), not about a side effect.

Didn't work as expected
2 4.0%
Didn't stop worms
1 2.0%

How soon problems started

Same day
36 73%
1–2 days
9 18%
3–7 days
1 2.0%
1–4 weeks
1 2.0%
Over a month
2 4.1%

Time from the first dose to the first sign, where both dates were reported (49 reports).

How the animals did

Recovered
5 10%
Still unwell when reported
36 72%
Not known
9 18%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other dewormers for cats