Vomiting after Diphenhydramine in cats

The FDA has received 163 reports of vomiting in cats after Diphenhydramine. That is 44% of all reports for this medicine, compared with 18% across reports for all cat medicines, so it is reported unusually often with this medicine.

163Reports
70%Marked serious
37%Recovered
24%Died or euthanised
Same dayTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
114 77%
1–2 days
15 10%
3–7 days
6 4.0%
1–4 weeks
5 3.4%
Over a month
9 6.0%

How the animals did

Recovered
60 37%
Still unwell when reported
51 31%
Died
21 13%
Euthanised
18 11%
Not known
13 8.0%

Problems reported at the same time

Age of the animals

Under 1 year
19
1–3 years
48
4–7 years
54
8–11 years
22
12+ years
20

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause vomiting in cats?
163 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

All reported side effects of Diphenhydramine in cats · Medicines most reported with vomiting