Lethargy after Diphenhydramine in cats

118 reports to the FDA describe lethargy in cats given Diphenhydramine. That is 32% of all reports for this medicine, compared with 14% across reports for all cat medicines, so it is reported unusually often with this medicine.

118Reports
65%Marked serious
31%Recovered
21%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
64 57%
1–2 days
29 26%
3–7 days
9 8.0%
1–4 weeks
7 6.2%
Over a month
4 3.5%

How the animals did

Recovered
37 31%
Still unwell when reported
43 36%
Died
11 9.3%
Euthanised
14 12%
Not known
13 11%

Problems reported at the same time

Age of the animals

Under 1 year
23
1–3 years
33
4–7 years
27
8–11 years
23
12+ years
12

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause lethargy in cats?
118 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Diphenhydramine in cats · Medicines most reported with lethargy