Swelling after Diphenhydramine in cats

The FDA has received 54 reports of swelling in cats after Diphenhydramine. That is 15% of all reports for this medicine, compared with 1.9% across reports for all cat medicines, so it is reported unusually often with this medicine.

54Reports
80%Marked serious
30%Recovered
39%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
28 55%
1–2 days
12 24%
3–7 days
3 5.9%
1–4 weeks
7 14%
Over a month
1 2.0%

How the animals did

Recovered
16 30%
Still unwell when reported
10 19%
Died
11 20%
Euthanised
10 19%
Not known
7 13%

Problems reported at the same time

Age of the animals

Under 1 year
13
1–3 years
16
4–7 years
12
8–11 years
3
12+ years
10

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause swelling in cats?
54 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

All reported side effects of Diphenhydramine in cats · Medicines most reported with swelling