Fever after Polysulfated Glycosaminoglycan in horses

The FDA has received 65 reports of fever in horses after Polysulfated Glycosaminoglycan. That is 13% of all reports for this medicine, compared with 4.8% across reports for all horse medicines, so it is reported unusually often with this medicine.

65Reports
60%Marked serious
34%Recovered
6.2%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
6 15%
1–2 days
11 28%
3–7 days
5 13%
1–4 weeks
15 38%
Over a month
3 7.5%

How the animals did

Recovered
22 34%
Still unwell when reported
11 17%
Died
2 3.1%
Euthanised
2 3.1%
Not known
28 43%

Problems reported at the same time

42 65%
15 23%
Abnormal ultrasound finding
12 18%
Leucocytosis
8 12%
Lymphopenia
7 11%
Serum amyloid a high, blood
7 11%

Age of the animals

Under 1 year
0
1–3 years
9
4–7 years
18
8–11 years
10
12+ years
18

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause fever in horses?
65 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Fever with similar medicines

All reported side effects of Polysulfated Glycosaminoglycan in horses · Medicines most reported with fever