Reluctant to move after Moxidectin (ProHeart 6) in horses

21 reports to the FDA describe reluctant to move in horses given Moxidectin. That is 1.5% of all reports for this medicine, compared with 1.0% across reports for all horse medicines, so it is reported unusually often with this medicine.

21Reports
0.0%Marked serious
0.0%Recovered
24%Died or euthanised
–Typical onset
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How the animals did

Still unwell when reported
1 4.8%
Died
5 24%
Not known
15 71%

Problems reported at the same time

5 24%
3 14%
Muscle stiffness
2 9.5%
Locomotor disturbance
2 9.5%

Age of the animals

Under 1 year
5
1–3 years
3
4–7 years
1
8–11 years
4
12+ years
6

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause reluctant to move in horses?
21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Moxidectin in horses · Medicines most reported with reluctant to move