Didn't work as expected after Misoprostol in horses

105 reports to the FDA describe didn't work as expected in horses given Misoprostol. That is 99% of all reports for this medicine, compared with 23% across reports for all horse medicines, so it is reported unusually often with this medicine.

105Reports
0.0%Marked serious
10%Recovered
0.0%Died or euthanised
35 daysTypical onset
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How soon it started

Same day
5 4.9%
1–2 days
1 1.0%
3–7 days
1 1.0%
1–4 weeks
32 31%
Over a month
63 62%

How the animals did

Recovered
11 10%
Still unwell when reported
29 28%
Not known
65 62%

Problems reported at the same time

Overdose
3 2.9%
Kidney problems
2 1.9%
Neutropenia
2 1.9%
Underdose
2 1.9%
Leucopenia
1 1.0%
Elevated gamma-glutamyl transferase (ggt)
1 1.0%
Lymphopenia
1 1.0%
Decreased haemoglobin
1 1.0%

Age of the animals

Under 1 year
0
1–3 years
3
4–7 years
25
8–11 years
28
12+ years
31

About this medicine

Type: medicine.

Questions owners ask

Can Misoprostol cause didn't work as expected in horses?
105 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 35 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

All reported side effects of Misoprostol in horses · Medicines most reported with didn't work as expected