Skin redness after Ivermectin + Praziquantel in horses

197 reports to the FDA describe skin redness in horses given Ivermectin + Praziquantel. That is 7.4% of all reports for this medicine, compared with 1.3% across reports for all horse medicines, so it is reported unusually often with this medicine.

197Reports

38%Marked serious

20%Recovered

0.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

41 71%

1–2 days

4 6.9%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

13 22%

How the animals did

Recovered

39 20%

Still unwell when reported

9 4.6%

Not known

149 76%

Problems reported at the same time

Swelling

146 74%

Application site reaction

53 27%

48 24%

45 23%

41 21%

30 15%

28 14%

23 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

103

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel cause skin redness in horses?: 197 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Ivermectin + Praziquantel in horses · Medicines most reported with skin redness