Liver disorder after Ursodiol in dogs

The FDA has received 23 reports of liver disorder in dogs after Ursodiol. That is 3.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

23Reports

83%Marked serious

4.3%Recovered

48%Died or euthanised

8 daysTypical onset

How soon it started

Same day

4 20%

1–2 days

3 15%

3–7 days

3 15%

1–4 weeks

7 35%

Over a month

3 15%

How the animals did

Recovered

1 4.3%

Still unwell when reported

7 30%

Died

5 22%

Euthanised

6 26%

Not known

4 17%

Problems reported at the same time

Liver problems

21 91%

Lethargy

14 61%

Loss of appetite

14 61%

Abnormal ultrasound finding

13 57%

Death

11 48%

Vomiting

11 48%

Kidney problems

11 48%

Gall bladder & bile duct disorder

10 43%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Ursodiol cause liver disorder in dogs?: 23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver disorder with similar medicines

Liver disorder after Tramadol 30 reports · 0.8% of its reports
Liver disorder after Famotidine 31 reports · 1.2% of its reports
Liver disorder after Chondroitin + Glucosamine 21 reports · 0.8% of its reports
Liver disorder after Ampicillin 23 reports · 2.4% of its reports

All reported side effects of Ursodiol in dogs · Medicines most reported with liver disorder