Knuckling after Trazodone in dogs

22 reports to the FDA describe knuckling in dogs given Trazodone. That is 0.9% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

22Reports

86%Marked serious

0.0%Recovered

23%Died or euthanised

2 daysTypical onset

How soon it started

Same day

2 14%

1–2 days

6 43%

3–7 days

3 21%

1–4 weeks

1 7.1%

Over a month

2 14%

How the animals did

Still unwell when reported

17 77%

Euthanised

5 23%

Problems reported at the same time

6 27%

6 27%

6 27%

5 23%

5 23%

5 23%

5 23%

Proprioception deficit

5 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trazodone reduces anxiety and stress.

Questions owners ask

Can Trazodone cause knuckling in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Knuckling with similar medicines

Knuckling after Gabapentin 160 reports · 1.8% of its reports

All reported side effects of Trazodone in dogs · Medicines most reported with knuckling