Bradycardia after Tiletamine + Zolazepam in dogs

The FDA has received 51 reports of bradycardia in dogs after Tiletamine + Zolazepam. That is 3.5% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

51Reports
51%Marked serious
47%Recovered
20%Died or euthanised
Same dayTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
31 97%
1–2 days
0 0.0%
3–7 days
0 0.0%
1–4 weeks
1 3.1%
Over a month
0 0.0%

How the animals did

Recovered
24 47%
Still unwell when reported
5 9.8%
Died
10 20%
Not known
12 24%

Problems reported at the same time

10 20%
9 18%
Hypothermia
5 9.8%
Sedation
5 9.8%
5 9.8%

Age of the animals

Under 1 year
10
1–3 years
10
4–7 years
4
8–11 years
5
12+ years
2

About this medicine

Type: medicine.

Questions owners ask

Can Tiletamine + Zolazepam cause bradycardia in dogs?
51 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Bradycardia with similar medicines

All reported side effects of Tiletamine + Zolazepam in dogs · Medicines most reported with bradycardia