Bradycardia after Isoflurane in dogs

The FDA has received 320 reports of bradycardia in dogs after Isoflurane. That is 12% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

320Reports
61%Marked serious
57%Recovered
18%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
208 95%
1–2 days
4 1.8%
3–7 days
3 1.4%
1–4 weeks
2 0.9%
Over a month
3 1.4%

How the animals did

Recovered
178 56%
Recovered with lasting effects
3 0.9%
Still unwell when reported
23 7.2%
Died
53 17%
Euthanised
3 0.9%
Not known
60 19%

Problems reported at the same time

Age of the animals

Under 1 year
63
1–3 years
67
4–7 years
66
8–11 years
64
12+ years
9

About this medicine

Type: medicine.

Questions owners ask

Can Isoflurane cause bradycardia in dogs?
320 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Bradycardia with similar medicines

All reported side effects of Isoflurane in dogs · Medicines most reported with bradycardia