Apnoea after Tiletamine + Zolazepam in dogs

The FDA has received 91 reports of apnoea in dogs after Tiletamine + Zolazepam. That is 6.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

91Reports
16%Marked serious
18%Recovered
55%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
17 94%
1–2 days
1 5.6%
3–7 days
0 0.0%
1–4 weeks
0 0.0%
Over a month
0 0.0%

How the animals did

Recovered
16 18%
Died
49 54%
Euthanised
1 1.1%
Not known
25 27%

Problems reported at the same time

50 55%
10 11%
8 8.8%
Bradypnoea
5 5.5%
5 5.5%

Age of the animals

Under 1 year
25
1–3 years
19
4–7 years
16
8–11 years
7
12+ years
1

About this medicine

Type: medicine.

Questions owners ask

Can Tiletamine + Zolazepam cause apnoea in dogs?
91 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Apnoea with similar medicines

All reported side effects of Tiletamine + Zolazepam in dogs · Medicines most reported with apnoea