Systemic disorder after Spinosad (Comfortis) in dogs

119 reports to the FDA describe systemic disorder in dogs given Spinosad. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

119Reports

52%Marked serious

41%Recovered

29%Died or euthanised

1 daysTypical onset

How soon it started

Same day

32 46%

1–2 days

7 10%

3–7 days

2 2.9%

1–4 weeks

5 7.1%

Over a month

24 34%

How the animals did

Recovered

25 21%

Recovered with lasting effects

24 20%

Still unwell when reported

7 5.9%

Died

24 20%

Euthanised

11 9.2%

Not known

28 24%

Problems reported at the same time

40 34%

39 33%

35 29%

30 25%

19 16%

18 15%

17 14%

15 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause systemic disorder in dogs?: 119 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Systemic disorder with similar medicines

Systemic disorder after Lufenuron + Milbemycin Oxime (Sentinel) 39 reports · 0.1% of its reports
Systemic disorder after Nitenpyram (Capstar) 31 reports · 0.3% of its reports
Systemic disorder after Fipronil + S-methoprene (Frontline Plus) 20 reports · 0.7% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with systemic disorder