Not sleeping after Spinosad (Comfortis) in dogs

29 reports to the FDA describe not sleeping in dogs given Spinosad. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported less often than average with this medicine.

29Reports

34%Marked serious

72%Recovered

0.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

10 56%

1–2 days

2 11%

3–7 days

1 5.6%

1–4 weeks

0 0.0%

Over a month

5 28%

How the animals did

Recovered

14 48%

Recovered with lasting effects

7 24%

Still unwell when reported

1 3.4%

Not known

7 24%

Problems reported at the same time

Restlessness or agitation

9 31%

9 31%

9 31%

8 28%

8 28%

7 24%

5 17%

4 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause not sleeping in dogs?: 29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not sleeping with similar medicines

Not sleeping after Cyphenothrin + Fipronil + S-methoprene 38 reports · 5.9% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with not sleeping