Malaise after Spinosad (Comfortis) in dogs

161 reports to the FDA describe malaise in dogs given Spinosad. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

161Reports
25%Marked serious
39%Recovered
11%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
52 51%
1–2 days
14 14%
3–7 days
4 4.0%
1–4 weeks
4 4.0%
Over a month
27 27%

How the animals did

Recovered
57 35%
Recovered with lasting effects
6 3.7%
Still unwell when reported
26 16%
Died
11 6.8%
Euthanised
6 3.7%
Not known
55 34%

Problems reported at the same time

Age of the animals

Under 1 year
14
1–3 years
38
4–7 years
46
8–11 years
23
12+ years
22

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause malaise in dogs?
161 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Malaise with similar medicines

All reported side effects of Spinosad in dogs · Medicines most reported with malaise