Hyperglycaemia after Spinosad (Comfortis) in dogs

177 reports to the FDA describe hyperglycaemia in dogs given Spinosad. That is 0.3% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

177Reports
60%Marked serious
28%Recovered
26%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
33 33%
1–2 days
19 19%
3–7 days
5 5.0%
1–4 weeks
2 2.0%
Over a month
42 42%

How the animals did

Recovered
19 11%
Recovered with lasting effects
30 17%
Still unwell when reported
21 12%
Died
26 15%
Euthanised
20 11%
Not known
61 34%

Problems reported at the same time

Age of the animals

Under 1 year
21
1–3 years
45
4–7 years
46
8–11 years
48
12+ years
16

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause hyperglycaemia in dogs?
177 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperglycaemia with similar medicines

All reported side effects of Spinosad in dogs · Medicines most reported with hyperglycaemia