Glazed eye after Spinosad (Comfortis) in dogs

The FDA has received 110 reports of glazed eye in dogs after Spinosad. That is 0.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.

110Reports

25%Marked serious

41%Recovered

8.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

34 63%

1–2 days

5 9.3%

3–7 days

0 0.0%

1–4 weeks

2 3.7%

Over a month

13 24%

How the animals did

Recovered

34 31%

Recovered with lasting effects

11 10%

Still unwell when reported

2 1.8%

Died

7 6.4%

Euthanised

2 1.8%

Not known

54 49%

Problems reported at the same time

63 57%

32 29%

31 28%

20 18%

18 16%

15 14%

15 14%

11 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause glazed eye in dogs?: 110 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Glazed eye with similar medicines

Glazed eye after Lufenuron + Milbemycin Oxime (Sentinel) 22 reports · 0.1% of its reports
Glazed eye after Imidacloprid + Moxidectin (Advantage Multi) 32 reports · 0.2% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with glazed eye