Elevated temperature after Spinosad (Comfortis) in dogs

The FDA has received 92 reports of elevated temperature in dogs after Spinosad. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

92Reports
51%Marked serious
58%Recovered
12%Died or euthanised
1 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
33 50%
1–2 days
3 4.5%
3–7 days
4 6.1%
1–4 weeks
8 12%
Over a month
18 27%

How the animals did

Recovered
34 37%
Recovered with lasting effects
19 21%
Still unwell when reported
12 13%
Died
6 6.5%
Euthanised
5 5.4%
Not known
16 17%

Problems reported at the same time

Age of the animals

Under 1 year
13
1–3 years
24
4–7 years
35
8–11 years
18
12+ years
2

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause elevated temperature in dogs?
92 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated temperature with similar medicines

All reported side effects of Spinosad in dogs · Medicines most reported with elevated temperature