Decreased urine concentration after Spinosad (Comfortis) in dogs

69 reports to the FDA describe decreased urine concentration in dogs given Spinosad. That is 0.1% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

69Reports

35%Marked serious

13%Recovered

25%Died or euthanised

20 daysTypical onset

How soon it started

Same day

6 24%

1–2 days

4 16%

3–7 days

0 0.0%

1–4 weeks

4 16%

Over a month

11 44%

How the animals did

Recovered

3 4.3%

Recovered with lasting effects

6 8.7%

Still unwell when reported

8 12%

Died

13 19%

Euthanised

4 5.8%

Not known

35 51%

Problems reported at the same time

35 51%

32 46%

29 42%

28 41%

28 41%

26 38%

20 29%

18 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause decreased urine concentration in dogs?: 69 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 20 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased urine concentration with similar medicines

Decreased urine concentration after Lufenuron + Milbemycin Oxime (Sentinel) 38 reports · 0.1% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with decreased urine concentration