Decreased activity after Spinosad (Comfortis) in dogs

111 reports to the FDA describe decreased activity in dogs given Spinosad. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

111Reports

31%Marked serious

59%Recovered

9.0%Died or euthanised

1 daysTypical onset

How soon it started

Same day

39 49%

1–2 days

10 13%

3–7 days

5 6.3%

1–4 weeks

2 2.5%

Over a month

24 30%

How the animals did

Recovered

48 43%

Recovered with lasting effects

17 15%

Still unwell when reported

16 14%

Died

8 7.2%

Euthanised

2 1.8%

Not known

20 18%

Problems reported at the same time

48 43%

31 28%

28 25%

25 23%

15 14%

14 13%

11 9.9%

10 9.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause decreased activity in dogs?: 111 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased activity with similar medicines

Decreased activity after Lufenuron + Milbemycin Oxime (Sentinel) 26 reports · 0.1% of its reports
Decreased activity after Nitenpyram (Capstar) 47 reports · 0.4% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with decreased activity