Behaviour change after Phenobarbital in dogs

The FDA has received 75 reports of behaviour change in dogs after Phenobarbital. That is 4.9% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

75Reports
72%Marked serious
33%Recovered
23%Died or euthanised
13 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
10 24%
1–2 days
4 9.5%
3–7 days
5 12%
1–4 weeks
4 9.5%
Over a month
19 45%

How the animals did

Recovered
19 25%
Recovered with lasting effects
6 8.0%
Still unwell when reported
15 20%
Died
5 6.7%
Euthanised
12 16%
Not known
18 24%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
7
4–7 years
18
8–11 years
26
12+ years
22

About this medicine

Type: medicine.

Questions owners ask

Can Phenobarbital cause behaviour change in dogs?
75 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 13 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Phenobarbital in dogs · Medicines most reported with behaviour change