Localised rash after Moxidectin (ProHeart 6) in dogs

30 reports to the FDA describe localised rash in dogs given Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.

30Reports
60%Marked serious
20%Recovered
0.0%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
16 62%
1–2 days
4 15%
3–7 days
1 3.8%
1–4 weeks
5 19%
Over a month
0 0.0%

How the animals did

Recovered
6 20%
Still unwell when reported
23 77%
Not known
1 3.3%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
17
4–7 years
7
8–11 years
5
12+ years
0

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause localised rash in dogs?
30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Localised rash with similar medicines

All reported side effects of Moxidectin in dogs · Medicines most reported with localised rash