Elevated creatine-kinase (ck) after Moxidectin (ProHeart 6) in dogs
68 reports to the FDA describe elevated creatine-kinase (ck) in dogs given Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.
68Reports
34%Marked serious
1.5%Recovered
26%Died or euthanised
1 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).
Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Moxidectin cause elevated creatine-kinase (ck) in dogs?
- 68 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 1 day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Elevated creatine-kinase (ck) with similar medicines
- Elevated creatine-kinase (ck) after Ivermectin + Pyrantel (Heartgard Plus) 59 reports · 0.0% of its reports
- Elevated creatine-kinase (ck) after Milbemycin Oxime + Spinosad (Trifexis) 37 reports · 0.0% of its reports
All reported side effects of Moxidectin in dogs · Medicines most reported with elevated creatine-kinase (ck)