Dehydration after Moxidectin (ProHeart 6) in dogs

408 reports to the FDA describe dehydration in dogs given Moxidectin. That is 0.8% of all reports for this medicine, compared with 0.7% across reports for all dog medicines.

408Reports

47%Marked serious

13%Recovered

21%Died or euthanised

1 daysTypical onset

How soon it started

Same day

127 46%

1–2 days

65 24%

3–7 days

35 13%

1–4 weeks

25 9.1%

Over a month

23 8.4%

How the animals did

Recovered

52 13%

Recovered with lasting effects

1 0.2%

Still unwell when reported

176 43%

Died

54 13%

Euthanised

30 7.4%

Not known

95 23%

Problems reported at the same time

261 64%

238 58%

207 51%

154 38%

123 30%

93 23%

83 20%

65 16%

Age of the animals

Under 1 year

1–3 years

138

4–7 years

132

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause dehydration in dogs?: 408 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dehydration with similar medicines

Dehydration after Ivermectin + Pyrantel (Heartgard Plus) 322 reports · 0.2% of its reports
Dehydration after Milbemycin Oxime + Spinosad (Trifexis) 624 reports · 0.5% of its reports
Dehydration after Milbemycin Oxime + Praziquantel (Interceptor Plus) 133 reports · 0.4% of its reports
Dehydration after Milbemycin Oxime (Interceptor) 135 reports · 0.5% of its reports
Dehydration after Selamectin (Revolution) 106 reports · 0.4% of its reports
Dehydration after Ivermectin (Heartgard) 93 reports · 0.8% of its reports
Dehydration after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 32 reports · 0.4% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with dehydration