Circling - neurological disorder after Moxidectin (ProHeart 6) in dogs

86 reports to the FDA describe circling - neurological disorder in dogs given Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

86Reports

50%Marked serious

13%Recovered

37%Died or euthanised

1 daysTypical onset

How soon it started

Same day

20 39%

1–2 days

15 29%

3–7 days

7 14%

1–4 weeks

5 9.8%

Over a month

4 7.8%

How the animals did

Recovered

11 13%

Still unwell when reported

22 26%

Died

25 29%

Euthanised

7 8.1%

Not known

21 24%

Problems reported at the same time

38 44%

33 38%

28 33%

23 27%

23 27%

22 26%

15 17%

Eye or vision problems

15 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause circling - neurological disorder in dogs?: 86 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Circling - neurological disorder with similar medicines

Circling - neurological disorder after Ivermectin + Pyrantel (Heartgard Plus) 139 reports · 0.1% of its reports
Circling - neurological disorder after Milbemycin Oxime + Spinosad (Trifexis) 147 reports · 0.1% of its reports
Circling - neurological disorder after Milbemycin Oxime + Praziquantel (Interceptor Plus) 24 reports · 0.1% of its reports
Circling - neurological disorder after Milbemycin Oxime (Interceptor) 25 reports · 0.1% of its reports
Circling - neurological disorder after Selamectin (Revolution) 70 reports · 0.2% of its reports
Circling - neurological disorder after Ivermectin (Heartgard) 22 reports · 0.2% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with circling - neurological disorder