Blood problems after Misoprostol in dogs

The FDA has received 22 reports of blood problems in dogs after Misoprostol. That is 35% of all reports for this medicine, compared with 1.8% across reports for all dog medicines, so it is reported unusually often with this medicine.

22Reports
77%Marked serious
9.1%Recovered
55%Died or euthanised
14 daysTypical onset
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How soon it started

Same day
3 15%
1–2 days
2 10%
3–7 days
4 20%
1–4 weeks
4 20%
Over a month
7 35%

How the animals did

Recovered
1 4.5%
Recovered with lasting effects
1 4.5%
Still unwell when reported
8 36%
Died
2 9.1%
Euthanised
10 45%

Problems reported at the same time

13 59%
12 55%
10 45%
Leucocytosis
7 32%
Kidney problems
7 32%
Hypoproteinaemia
7 32%

Age of the animals

Under 1 year
4
1–3 years
3
4–7 years
9
8–11 years
3
12+ years
3

About this medicine

Type: medicine.

Questions owners ask

Can Misoprostol cause blood problems in dogs?
22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 14 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood problems with similar medicines

All reported side effects of Misoprostol in dogs · Medicines most reported with blood problems