Appetite loss after Milbemycin Oxime (Interceptor) in dogs

22 reports to the FDA describe appetite loss in dogs given Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

22Reports

32%Marked serious

23%Recovered

0.0%Died or euthanised

9 daysTypical onset

How soon it started

Same day

3 19%

1–2 days

4 25%

3–7 days

1 6.3%

1–4 weeks

1 6.3%

Over a month

7 44%

How the animals did

Recovered

5 23%

Still unwell when reported

11 50%

Not known

6 27%

Problems reported at the same time

9 41%

9 41%

4 18%

3 14%

3 14%

2 9.1%

2 9.1%

2 9.1%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause appetite loss in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 9 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Appetite loss with similar medicines

Appetite loss after Ivermectin + Pyrantel (Heartgard Plus) 283 reports · 0.2% of its reports
Appetite loss after Milbemycin Oxime + Spinosad (Trifexis) 524 reports · 0.4% of its reports
Appetite loss after Moxidectin (ProHeart 6) 45 reports · 0.1% of its reports
Appetite loss after Milbemycin Oxime + Praziquantel (Interceptor Plus) 76 reports · 0.2% of its reports
Appetite loss after Ivermectin (Heartgard) 33 reports · 0.3% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with appetite loss