Reddening of the skin after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

101 reports to the FDA describe reddening of the skin in dogs given Milbemycin Oxime + Praziquantel. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

101Reports

23%Marked serious

28%Recovered

0.0%Died or euthanised

4 daysTypical onset

How soon it started

Same day

24 31%

1–2 days

13 17%

3–7 days

3 3.9%

1–4 weeks

4 5.2%

Over a month

33 43%

How the animals did

Recovered

28 28%

Still unwell when reported

54 53%

Not known

19 19%

Problems reported at the same time

46 46%

20 20%

18 18%

16 16%

14 14%

13 13%

Skin rash or irritation

13 13%

Hair loss

13 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause reddening of the skin in dogs?: 101 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Reddening of the skin with similar medicines

Reddening of the skin after Ivermectin + Pyrantel (Heartgard Plus) 173 reports · 0.1% of its reports
Reddening of the skin after Milbemycin Oxime + Spinosad (Trifexis) 729 reports · 0.6% of its reports
Reddening of the skin after Moxidectin (ProHeart 6) 485 reports · 1.0% of its reports
Reddening of the skin after Selamectin (Revolution) 51 reports · 0.2% of its reports
Reddening of the skin after Ivermectin (Heartgard) 32 reports · 0.3% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with reddening of the skin