Dysphoria after Midazolam in dogs

The FDA has received 22 reports of dysphoria in dogs after Midazolam. That is 1.8% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

22Reports

73%Marked serious

55%Recovered

9.1%Died or euthanised

Same dayTypical onset

How soon it started

Same day

15 75%

1–2 days

2 10%

3–7 days

1 5.0%

1–4 weeks

1 5.0%

Over a month

1 5.0%

How the animals did

Recovered

12 55%

Still unwell when reported

5 23%

Died

1 4.5%

Euthanised

1 4.5%

Not known

3 14%

Problems reported at the same time

Didn't work as expected

6 27%

Vocalising

6 27%

Nystagmus

3 14%

Seizures

3 14%

Underdose

2 9.1%

Liver problems

2 9.1%

Tachycardia

2 9.1%

Tremors

2 9.1%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Midazolam cause dysphoria in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dysphoria with similar medicines

Dysphoria after Butorphanol 24 reports · 0.5% of its reports
Dysphoria after Propofol 21 reports · 0.7% of its reports
Dysphoria after Isoflurane 29 reports · 1.0% of its reports

All reported side effects of Midazolam in dogs · Medicines most reported with dysphoria