Prolonged activated partial thrombin time (aptt) after Metronidazole in dogs

The FDA has received 25 reports of prolonged activated partial thrombin time (aptt) in dogs after Metronidazole. That is 0.8% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

25Reports

92%Marked serious

12%Recovered

40%Died or euthanised

3 daysTypical onset

How soon it started

Same day

4 21%

1–2 days

3 16%

3–7 days

6 32%

1–4 weeks

4 21%

Over a month

2 11%

How the animals did

Recovered

2 8.0%

Recovered with lasting effects

1 4.0%

Still unwell when reported

11 44%

Died

3 12%

Euthanised

7 28%

Not known

1 4.0%

Problems reported at the same time

18 72%

17 68%

16 64%

15 60%

15 60%

Prolonged one stage prothrombin time (ospt)

14 56%

Blood problems

11 44%

Death

10 40%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Metronidazole treats some bacterial and parasitic gut infections.

Questions owners ask

Can Metronidazole cause prolonged activated partial thrombin time (aptt) in dogs?: 25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Prolonged activated partial thrombin time (aptt) with similar medicines

Prolonged activated partial thrombin time (aptt) after Enrofloxacin (Baytril) 20 reports · 0.5% of its reports

All reported side effects of Metronidazole in dogs · Medicines most reported with prolonged activated partial thrombin time (aptt)