Prolonged one stage prothrombin time (ospt) after Maropitant (Cerenia) in dogs

The FDA has received 78 reports of prolonged one stage prothrombin time (ospt) in dogs after Maropitant. That is 0.7% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

78Reports

92%Marked serious

14%Recovered

49%Died or euthanised

3 daysTypical onset

How soon it started

Same day

26 38%

1–2 days

6 8.7%

3–7 days

20 29%

1–4 weeks

9 13%

Over a month

8 12%

How the animals did

Recovered

10 13%

Recovered with lasting effects

1 1.3%

Still unwell when reported

23 29%

Died

16 21%

Euthanised

22 28%

Not known

6 7.7%

Problems reported at the same time

62 79%

48 62%

39 50%

38 49%

Prolonged activated partial thrombin time (aptt)

38 49%

Kidney problems

37 47%

Lethargy

33 42%

Blood problems

30 38%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Maropitant prevents vomiting and motion sickness.

Products with this ingredient include Cerenia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Maropitant cause prolonged one stage prothrombin time (ospt) in dogs?: 78 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Maropitant in dogs · Medicines most reported with prolonged one stage prothrombin time (ospt)