Prolonged activated partial thrombin time (aptt) after Maropitant (Cerenia) in dogs

The FDA has received 86 reports of prolonged activated partial thrombin time (aptt) in dogs after Maropitant. That is 0.7% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

86Reports

88%Marked serious

9.3%Recovered

48%Died or euthanised

2 daysTypical onset

How soon it started

Same day

25 33%

1–2 days

15 20%

3–7 days

16 21%

1–4 weeks

9 12%

Over a month

10 13%

How the animals did

Recovered

7 8.1%

Recovered with lasting effects

1 1.2%

Still unwell when reported

35 41%

Died

16 19%

Euthanised

25 29%

Not known

2 2.3%

Problems reported at the same time

62 72%

53 62%

44 51%

41 48%

38 44%

38 44%

Prolonged one stage prothrombin time (ospt)

38 44%

Loss of appetite

37 43%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Maropitant prevents vomiting and motion sickness.

Products with this ingredient include Cerenia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Maropitant cause prolonged activated partial thrombin time (aptt) in dogs?: 86 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Maropitant in dogs · Medicines most reported with prolonged activated partial thrombin time (aptt)