Staggering after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) in dogs

25 reports to the FDA describe staggering in dogs given Ivermectin + Praziquantel + Pyrantel. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

25Reports

40%Marked serious

80%Recovered

4.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

16 73%

1–2 days

4 18%

3–7 days

1 4.5%

1–4 weeks

0 0.0%

Over a month

1 4.5%

How the animals did

Recovered

20 80%

Died

1 4.0%

Not known

4 16%

Problems reported at the same time

13 52%

10 40%

7 28%

4 16%

4 16%

4 16%

3 12%

Inappropriate defecation

3 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Iverhart Max. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel + Pyrantel cause staggering in dogs?: 25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Staggering with similar medicines

Staggering after Ivermectin + Pyrantel (Heartgard Plus) 275 reports · 0.2% of its reports
Staggering after Milbemycin Oxime + Spinosad (Trifexis) 150 reports · 0.1% of its reports
Staggering after Moxidectin (ProHeart 6) 83 reports · 0.2% of its reports
Staggering after Milbemycin Oxime + Praziquantel (Interceptor Plus) 25 reports · 0.1% of its reports
Staggering after Milbemycin Oxime (Interceptor) 38 reports · 0.1% of its reports
Staggering after Selamectin (Revolution) 35 reports · 0.1% of its reports
Staggering after Ivermectin (Heartgard) 88 reports · 0.7% of its reports

All reported side effects of Ivermectin + Praziquantel + Pyrantel in dogs · Medicines most reported with staggering