Polypnoea after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) in dogs

The FDA has received 31 reports of polypnoea in dogs after Ivermectin + Praziquantel + Pyrantel. That is 0.4% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

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How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Iverhart Max. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel + Pyrantel cause polypnoea in dogs?

31 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Polypnoea with similar medicines

• Polypnoea after Ivermectin + Pyrantel (Heartgard Plus) 144 reports · 0.1% of its reports
• Polypnoea after Milbemycin Oxime + Spinosad (Trifexis) 42 reports · 0.0% of its reports
• Polypnoea after Moxidectin (ProHeart 6) 229 reports · 0.5% of its reports
• Polypnoea after Milbemycin Oxime (Interceptor) 157 reports · 0.5% of its reports
• Polypnoea after Selamectin (Revolution) 184 reports · 0.6% of its reports
• Polypnoea after Ivermectin (Heartgard) 30 reports · 0.2% of its reports

All reported side effects of Ivermectin + Praziquantel + Pyrantel in dogs · Medicines most reported with polypnoea