Gastric perforation after Isoflurane in dogs

The FDA has received 26 reports of gastric perforation in dogs after Isoflurane. That is 0.9% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports

96%Marked serious

23%Recovered

50%Died or euthanised

4 daysTypical onset

How soon it started

Same day

2 8.3%

1–2 days

4 17%

3–7 days

11 46%

1–4 weeks

2 8.3%

Over a month

5 21%

How the animals did

Recovered

6 23%

Still unwell when reported

4 15%

Died

6 23%

Euthanised

7 27%

Not known

3 12%

Problems reported at the same time

20 77%

15 58%

13 50%

12 46%

12 46%

8 31%

8 31%

Abnormal ultrasound finding

8 31%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Isoflurane cause gastric perforation in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Gastric perforation with similar medicines

Gastric perforation after Tramadol 44 reports · 1.2% of its reports

All reported side effects of Isoflurane in dogs · Medicines most reported with gastric perforation