Malaise after Fluralaner (Bravecto) in dogs

The FDA has received 224 reports of malaise in dogs after Fluralaner. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

224Reports
79%Marked serious
20%Recovered
21%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
44 35%
1–2 days
26 21%
3–7 days
15 12%
1–4 weeks
16 13%
Over a month
24 19%

How the animals did

Recovered
37 17%
Recovered with lasting effects
7 3.1%
Still unwell when reported
96 43%
Died
20 8.9%
Euthanised
27 12%
Not known
37 17%

Problems reported at the same time

Age of the animals

Under 1 year
22
1–3 years
44
4–7 years
68
8–11 years
58
12+ years
23

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause malaise in dogs?
224 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Malaise with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with malaise